Exosome component 7

Protein-coding gene in the species Homo sapiens

EXOSC7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2NN6

Identifiers
AliasesEXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, Exosome component 7
External IDsOMIM: 606488; MGI: 1913696; HomoloGene: 8994; GeneCards: EXOSC7; OMA:EXOSC7 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for EXOSC7
Genomic location for EXOSC7
Band3p21.31Start44,975,241 bp[1]
End45,036,066 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for EXOSC7
Genomic location for EXOSC7
Band9|9 F4Start122,942,280 bp[2]
End122,965,194 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • thoracic diaphragm

  • skin of leg

  • right adrenal gland

  • left adrenal gland

  • skin of abdomen

  • left adrenal cortex

  • right adrenal cortex

  • body of tongue
Top expressed in
  • otic placode

  • morula

  • saccule

  • otic vesicle

  • primitive streak

  • embryo

  • epiblast

  • yolk sac

  • somite

  • blastocyst
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • 3'-5'-exoribonuclease activity
  • exoribonuclease activity
  • protein binding
  • RNA binding
Cellular component
  • cytoplasm
  • cytosol
  • exosome (RNase complex)
  • nucleolus
  • nucleoplasm
  • nucleus
  • nuclear exosome (RNase complex)
  • cytoplasmic exosome (RNase complex)
Biological process
  • regulation of mRNA stability
  • RNA catabolic process
  • rRNA processing
  • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
  • U1 snRNA 3'-end processing
  • U4 snRNA 3'-end processing
  • U5 snRNA 3'-end processing
  • exonucleolytic catabolism of deadenylated mRNA
  • nuclear mRNA surveillance
  • nuclear polyadenylation-dependent rRNA catabolic process
  • nuclear polyadenylation-dependent tRNA catabolic process
  • nuclear polyadenylation-dependent mRNA catabolic process
  • rRNA catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23016

66446

Ensembl

ENSG00000075914

ENSMUSG00000025785

UniProt

Q15024

Q9D0M0

RefSeq (mRNA)

NM_015004

NM_001081188
NM_025568

RefSeq (protein)

NP_055819

NP_001074657

Location (UCSC)Chr 3: 44.98 – 45.04 MbChr 9: 122.94 – 122.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.[5]

Interactions

Exosome component 7 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075914 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025785 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EXOSC7 exosome component 7".
  6. ^ a b c Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.
  7. ^ Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl:2066/261980. PMID 11812149.

Further reading

  • Butler JS (2002). "The yin and yang of the exosome". Trends Cell Biol. 12 (2): 90–6. doi:10.1016/S0962-8924(01)02225-5. PMID 11849973.
  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  • Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
  • Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl:2066/261980. PMID 11812149.
  • Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
  • Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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  • 2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
    2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40


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