Extended-spectrum penicillin
Group of antibiotics that have the widest antibacterial spectrum of all penicillins
The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins.[1] Some sources identify them with antipseudomonal penicillins,[2] others consider these types to be distinct.[3] This group includes the carboxypenicillins and the ureidopenicillins. Aminopenicillins, in contrast, do not have activity against Pseudomonas species, as their positively charged amino group does not hinder degradation by bacterially produced beta-lactamases.[4]
Products
- Ureidopenicillins
- Azlocillin
- Mezlocillin
- Piperacillin
- Carboxypenicillins
- Ticarcillin (generally in the combination ticarcillin/clavulanic acid)
- Carbenicillin
- Mecillinam
See also
- Pseudomonas aeruginosa § Treatment
References
- ^ Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917
- ^ Kester, Mark; Karpa, Kelly Dowhower; Vrana, Kent E. (2011). Elsevier's Integrated Review Pharmacology E-Book. Elsevier Health Sciences. ISBN 9781455727032.
- ^ Clark, Michelle A.; Harvey, Richard A.; Finkel, Richard; Rey, Jose A.; Whalen, Karen, eds. (2011). Pharmacology. Lippincott Williams & Wilkins. p. 383. ISBN 9781451113143.
- ^ Golan, David E. (15 December 2011). Principles of Pharmacology (2 ed.). Lippincott Williams & Wilkins. p. 610. ISBN 978-1608312702.
- v
- t
- e
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)
Lipopeptides |
|
---|---|
Other |
|
- Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid#
- Teixobactin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III