Protein-coding gene in the species Homo sapiens
OR5P3 |
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Identifiers |
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Aliases | OR5P3, JCG1, olfactory receptor family 5 subfamily P member 3 |
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External IDs | MGI: 3030342; HomoloGene: 72039; GeneCards: OR5P3; OMA:OR5P3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11p15.4 | Start | 7,824,818 bp[1] |
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End | 7,830,840 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 E3 | Start | 108,229,201 bp[2] |
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End | 108,230,835 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - skin of abdomen
- skin of leg
- urinary bladder
- lactiferous gland
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- odorant binding
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000182334 ENSG00000280808 ENSG00000278253 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 7.82 – 7.83 Mb | Chr 7: 108.23 – 108.23 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Olfactory receptor 5P3 is a protein that in humans is encoded by the OR5P3 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
The OR5P3 receptor is associated with examples of ligands includes:[6][7]
- 1-octanol
- celery ketone
- (-)-carvone
See also
References
- ^ a b c ENSG00000280808, ENSG00000278253 GRCh38: Ensembl release 89: ENSG00000182334, ENSG00000280808, ENSG00000278253 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063764 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR5P3 olfactory receptor, family 5, subfamily P, member 3".
- ^ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.
- ^ Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, et al. (September 2008). "Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor". Chemical Senses. 33 (7): 639–53. doi:10.1093/chemse/bjn032. PMID 18603653.
Further reading
- Gaudin JC, Breuils L, Haertlé T (November 2001). "New GPCRs from a human lingual cDNA library". Chemical Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
- Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 11 | |
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