PSME4

Protein found in humans

PSME4

Identifiers

Aliases

PSME4, PA200, proteasome activator subunit 4

External IDs

OMIM: 607705; MGI: 2143994; HomoloGene: 113742; GeneCards: PSME4; OMA:PSME4 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p16.2	Start	53,864,069 bp^[1]
Band	2p16.2	End	53,970,993 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A4	Start	30,721,726 bp^[2]
Band	11\|11 A4	End	30,830,361 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

glutes

gastrocnemius muscle

left testis

biceps brachii

right testis

Skeletal muscle tissue of biceps brachii

deltoid muscle

triceps brachii muscle

vastus lateralis muscle

Top expressed in

temporal muscle

triceps brachii muscle

vastus lateralis muscle

sternocleidomastoid muscle

digastric muscle

myocardium of ventricle

gastrocnemius muscle

spermatid

medial head of gastrocnemius muscle

cardiac muscles

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding peptidase activator activity lysine-acetylated histone binding proteasome binding
Cellular component	cytoplasm nuclear speck proteasome complex nucleus nucleoplasm cytosol proteasome core complex spermatoproteasome complex
Biological process	cell differentiation regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade cellular response to DNA damage stimulus positive regulation of peptidase activity multicellular organism development Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling spermatogenesis anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway DNA repair proteasome-mediated ubiquitin-dependent protein catabolic process Wnt signaling pathway, planar cell polarity pathway proteasomal ubiquitin-independent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23198


103554

Ensembl


ENSG00000068878


ENSMUSG00000040850

UniProt


Q14997


Q5SSW2

RefSeq (mRNA)


NM_014614


NM_134013

RefSeq (protein)


NP_055429


NP_598774

Location (UCSC)

Chr 2: 53.86 – 53.97 Mb

Chr 11: 30.72 – 30.83 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068878 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040850 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
^ Ustrell V, Hoffman L, Pratt G, Rechsteiner M (Jul 2002). "PA200, a nuclear proteasome activator involved in DNA repair". The EMBO Journal. 21 (13): 3516–25. doi:10.1093/emboj/cdf333. PMC 126083. PMID 12093752.
^ "Entrez Gene: PSME4 proteasome (prosome, macropain) activator subunit 4".

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