SUGT1

Human protein and coding gene

SUGT1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1RL1

Identifiers

Aliases

SUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

External IDs

OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q14.3	Start	52,652,709 bp^[1]
Band	13q14.3	End	52,700,909 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 D3	Start	79,825,131 bp^[2]
Band	14\|14 D3	End	79,872,636 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cardiac muscle tissue of right atrium

pancreatic epithelial cell

myocardium of left ventricle

oocyte

cartilage tissue

parietal pleura

tibia

pancreatic ductal cell

gingival epithelium

tendon of biceps brachii

Top expressed in

morula

morula

blastocyst

otic vesicle

medial ganglionic eminence

abdominal wall

epiblast

superior surface of tongue

otic placode

spermatid

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm cytosol nucleus kinetochore ubiquitin ligase complex protein-containing complex
Biological process	regulation of protein stability mitotic cell cycle protein stabilization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10910


67955

Ensembl


ENSG00000165416


ENSMUSG00000022024

UniProt


Q9Y2Z0


Q9CX34

RefSeq (mRNA)


NM_001130912 NM_006704 NM_001320831


NM_026474

RefSeq (protein)


NP_001124384 NP_001307760 NP_006695


NP_080750

Location (UCSC)

Chr 13: 52.65 – 52.7 Mb

Chr 14: 79.83 – 79.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.^[5]^[6]

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.^[6]

Interactions

SUGT1 has been shown to interact with S100A6.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
^ ^a ^b "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
^ Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
Niikura Y, Kitagawa K (December 2003). "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354. S2CID 20578581.
Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y (April 2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769. S2CID 37324928.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (April 2007). "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America. 104 (16): 6764–9. Bibcode:2007PNAS..104.6764D. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A (June 2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.