Flunitrazepam
![]() | |||
![]() | |||
(IUPAC) ime | |||
---|---|---|---|
6-(2-Fluorofenil)-2-metil-9-nitro-2,5-diazabiciklo[5.4.0]undeka-5,8,10,12-tetraen-3-on | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 1622-62-4 | ||
ATC kod | N05CD03 | ||
PubChem[1][2] | 3380 | ||
DrugBank | DB01544 | ||
ChemSpider[3] | 3263 | ||
UNII | 620X0222FQ ![]() | ||
KEGG[4] | D01230 ![]() | ||
ChEMBL[5] | CHEMBL13280 ![]() | ||
Hemijski podaci | |||
Formula | C16H12FN3O3 | ||
Mol. masa | 313,3 | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakokinetički podaci | |||
Bioraspoloživost | 64–77% (oralno) | ||
Metabolizam | Hepatički | ||
Poluvreme eliminacije | 18–26 sata | ||
Izlučivanje | Renalno | ||
Farmakoinformacioni podaci | |||
Trudnoća | C(AU) | ||
Pravni status | Droga (S8) (AU) CD No Reg POM (UK) Schedule IV (SAD) | ||
Način primene | Oralno |
Flunitrazepam (Narcozep, Rohypnol, Rohipnol, Roipnol, roofies[6]) benzodiazepin je srednje brzine dejstva koji se koristi kao hipnotik, sedativ, antikonvulsant, anksiolitik i miorelaksant drug.[7]
Flunitrazepam se uglavnom propisuje kao hipnotik za kratkotrajne tretmane hronične ili jake insomnije kad drugi lekovi nisu delotvorni, posebno tokom bolničke nege. On se smatra jednim od najefektivnijih benzodiazepinskih hipnotika. Poput drugih hipnotika, flunitrazepam se treba koristiti samo na kratkotrajnoj bazi ili povreneno.[8]
Flunitrazepam se klasifikuje kao nitro-benzodiazepin. On je fluorosani metilamino derivat nitrazepama. Drugi nitro-benzodiazepini su nitrazepam (roditeljsko jedinjenje), nimetazepam (metilamino derivat) i klonazepam (hlorinisani derivat).[9]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ NCBI
- ↑ Mandrioli R, Mercolini L, Raggi MA (October 2008). „Benzodiazepine metabolism: an analytical perspective”. Current Drug Metabolism 9 (8): 827–44. DOI:10.2174/138920008786049258. PMID 18855614. Arhivirano iz originala na datum 2009-03-17. Pristupljeno 2021-08-23.
- ↑ Rickels, K. (1986). „The clinical use of hypnotics: indications for use and the need for a variety of hypnotics”. Acta Psychiatrica Scandinavica Suppl. 74 (S332): 132–41. DOI:10.1111/j.1600-0447.1986.tb08990.x. PMID 2883820.
- ↑ Robertson MD; Drummer OH (May 1995). „Postmortem drug metabolism by bacteria”. Journal of Forensic Sciences 40 (3): 382–6. PMID 7782744.
Povezano
Spoljašnje veze
![]() | Portal Medicina |
![]() | Portal Hemija |
![](http://upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/15px-Commons-logo.svg.png)
- Inchem.org - Retrieved 2007-2-27
- Drugs Factfile on Rohypnol all you need to know
- Molecule of the Month
- Statement on "Date Rape" Drugs by Nicholas Reuter, M.P.H., Mar. 11, 1999. Arhivirano 2006-05-16 na Wayback Machine-u
- Club Drugs - Fact Sheet by Drug Policy Information Clearing House, United States.
- p
- r
- u
| |||||||||
| |||||||||
Dialkil-fenoli | |||||||||
CL-218,872 • Eszopiklon • Indiplon • Nekopidem • Pazinaklon • ROD-188 • Saripidem • Suproklon • Suriklon • SX-3228 • U-89843A • U-90042 • Zaleplon • Zolpidem • Zopiklon | |||||||||
Neuroaktivni steroidi |
receptor
Acetilholinski receptor
α1- adrenergički
Selektivni 5-HT2A & α1-adrenergički antagonisti |
---|
GHB receptor
GHB Tip |
---|
Oreksinski antagonisti |
---|
negrupisani
Drugi | 2-Metil-2-butanol • Acekarbromal • Acetofenon • Apronal • Bromidi • Bromizoval • Karbromal • Hloralosa • Klometiazol • Embutramid • Etomidat • Evoksin • Fenadiazol • Gaboksadol • Loreklezol • Mefenoksalon • Sulfonmetan • Trihloroetanol • Triklofos • Valerian • Valnoktamid |
---|