Flurazepam
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(IUPAC) ime | |||
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7-hloro-1-[2-(dietilamino)etil]-5-(2-fluorofenil)-1,3-dihidro-2H-1,4-benzodiazepin-2-on | |||
Klinički podaci | |||
Robne marke | Dalmane | ||
AHFS/Drugs.com | Monografija | ||
MedlinePlus | a682051 | ||
Identifikatori | |||
CAS broj | 17617-23-1 | ||
ATC kod | N05CD01 | ||
PubChem[1][2] | 3393 | ||
DrugBank | DB00690 | ||
ChemSpider[3] | 3276 | ||
UNII | IHP475989U ![]() | ||
KEGG[4] | D00329 ![]() | ||
ChEMBL[5] | CHEMBL968 ![]() | ||
Hemijski podaci | |||
Formula | C21H23ClFN3O | ||
Mol. masa | 387,88 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Fizički podaci | |||
Tačka topljenja | 79.5 °C (175 °F) | ||
Farmakokinetički podaci | |||
Bioraspoloživost | 83% | ||
Metabolizam | Hepatički | ||
Poluvreme eliminacije | 40–250 sata | ||
Izlučivanje | Renalno | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Schedule IV (SAD) | ||
Način primene | Oralno |
Flurazepam[6] (u prodaji pod imenima Dalmane i Dalmadorm) je lek iz benzodiazepinske klase. On poseduje anksiolitičkia, antikonvulsivna, sedativna i miorelaksantna svojstva. Iz flurazepama se formira metabolit sa veoma dugim poluživotom (40–250 sati), koji se može zadržati u krvi do četiri dana.[7] Flurazepam stoga nije podesan za primenu kao sredstvo za spavanje, jer uzrokuje sedaciju narednog dana, mada taj efekat može da olakša anksiozne poteškoće.[8][9][10][11][12][13][14]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ BE Patent 629005
- ↑ „Benzodiazepine Equivalence”. Arhivirano iz originala na datum 2007-07-17. Pristupljeno 2014-04-05.
- ↑ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
- ↑ Vermeeren A: Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. 2004;18(5):297-328. PMID 15089115
- ↑ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
- ↑ Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. PMID 18375
- ↑ Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. PMID 851373
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
Spoljašnje veze
![]() | Portal Medicina |
![]() | Portal Hemija |
- Rx-List - Flurazepam Arhivirano 2006-02-02 na Wayback Machine-u
- Inchem - Flurazepam
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Dialkil-fenoli | |||||||||
CL-218,872 • Eszopiklon • Indiplon • Nekopidem • Pazinaklon • ROD-188 • Saripidem • Suproklon • Suriklon • SX-3228 • U-89843A • U-90042 • Zaleplon • Zolpidem • Zopiklon | |||||||||
Neuroaktivni steroidi |
receptor
Acetilholinski receptor
α1- adrenergički
Selektivni 5-HT2A & α1-adrenergički antagonisti |
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GHB receptor
GHB Tip |
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Oreksinski antagonisti |
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negrupisani
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