Spermidin
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Identifikacija | |
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3D model (Jmol) |
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ChEBI |
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ChemSpider |
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DrugBank |
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ECHA InfoCard | 100.004.264 |
KEGG[1] |
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PubChem[2][3] C ID |
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SMILES
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Svojstva | |
C7H19N3 | |
Molarna masa | 145,246 |
Tačka topljenja | < |
Tačka ključanja | 129 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
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Reference infokutije | |
Spermidin je organsko jedinjenje, koje sadrži 7 atoma ugljenika i ima molekulsku masu od 145,246 Da.[4][5]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 3 |
Broj donora vodonika | 3 |
Broj rotacionih veza | 7 |
Particioni koeficijent[6] (ALogP) | -1,2 |
Rastvorljivost[7] (logS, log(mol/L)) | -1,5 |
Polarna površina[8] (PSA, Å2) | 64,1 |
Reference
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. уреди
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди
Literatura
- Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
- Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
- Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.
Spoljašnje veze
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Spermidin на Викимедијиној остави.
- Spermidine
- п
- р
- у
- Agonisti: Agonisti glavnog mesta: 5-Fluorovilardin
- Akromelična kiselina (akromelat)
- AMPA
- BOAA
- Domoinska kiselina
- Glutamat
- Ibotenska kiselina
- Prolin
- Kuiskualinska kiselina
- Vilardin; Pozitivni alosterni modulatori: Aniracetam
- Ciklotiazid
- CX-516
- CX-546
- CX-614
- Farampator (CX-691, ORG-24448)
- CX-717
- CX-1739
- CX-1942
- Diazoksid
- Hidrohlorotiazid (HTZ)
- IDRA-21
- LY-392098
- LY-395153
- LY-404187
- LY-451646
- LY-503430
- Mibampator (LY-451395)
- Nooglutil
- ORG-26576
- Oksiracetam
- PEPA
- PF-04958242
- Piracetam
- Pramiracetam
- S-18986
- Tulrampator (S-47445, CX-1632)
- Antagonisti: ACEA-1011
- ATPO
- Bekampanel
- Karoverin
- CNQX
- Dazolampanel
- DNQX
- Fanapanel (MPQX)
- GAMS
- Kaitocefalin
- Kinurenska kiselina
- Kinurenin
- Likostinel (ACEA-1021)
- NBQX
- PNQX
- Selurampanel
- Tezampanel
- Teanin
- Topiramat
- YM90K
- Zonampanel; Negativni alosterni modulatori: Barbiturati (npr. pentobarbital, natrijum tiopental)
- Ciklopropan
- Enfluran
- Etanol (alkohol)
- Evansovo plavo
- GYKI-52466
- GYKI-53655
- Halotan
- Irampanel
- Izofluran
- Perampanel
- Pregnenolon sulfat
- Sevofluran
- Talampanel; Nepoznati/nerazvrstani antagonisti: Minociklin
- Agonisti: Agonisti glavnog mesta: 5-Bromovilardin
- 5-Jodovilardin
- Akromelična kiselina (akromelat)
- AMPA
- ATPA
- Domoinska kiselina
- Glutamat
- Ibotenska kiselina
- Kainska kiselina
- LY-339434
- Prolin
- Kuiskualinska kiselina
- SYM-2081; Pozitivni alosterni modulatori: Ciklotiazid
- Diazoksid
- Enfluran
- Halotan
- Izofluran
- Antagonisti: ACEA-1011
- CNQX
- Dazolampanel
- DNQX
- GAMS
- Kaitocefalin
- Kinurenska kiselina
- Likostinel (ACEA-1021)
- LY-382884
- NBQX
- NS102
- Selurampanel
- Tezampanel
- Teanin
- Topiramat
- UBP-302; Negativni alosterni modulatori: Barbiturati (npr. pentobarbital, natrijum tiopental)
- Enfluran
- Etanol (alkohol)
- Evansovo plavo
- NS-3763
- Pregnenolon sulfat
- Agonisti: Agonisti glavnog mesta: AMAA
- Aspartat
- Glutamat
- Homocisteinska kiselina (L-HCA)
- Homohinolinska kiselina
- Ibotenska kiselina
- NMDA
- Prolin
- Hinolinska kiselina
- Tetrazolilglicin
- Teanin; Agonisti glicinovog mesta: β-fluoro-D-alanin
- ACBD
- ACC (ACPC)
- ACPD
- AK-51
- Apimostinel (NRX-1074)
- B6B21
- CCG
- D-Alanin
- D-Cikloserin
- D-Serin
- DHPG
- Dimetilglicin
- Glicin
- HA-966
- L-687414
- L-Alanin
- L-Serin
- Milacemid
- Neboglamin (nebostinel)
- Rapastinel (GLYX-13)
- Sarkozin; Agonisti poliaminovog mesta: Neomicin
- Spermidin
- Spermin; Ostali pozitivni alosterni modulatori: 24S-hidroksiholesterol
- DHEA (prasteron)
- DHEA sulfat (prasteron sulfat)
- Epipregnanolon sulfat
- Pregnenolon sulfat
- SAGE-201
- SAGE-301
- SAGE-718
- Antagonisti: Kompetitivni antagonisti: AP5 (APV)
- AP7
- CGP-37849
- CGP-39551
- CGP-39653
- CGP-40116
- CGS-19755
- CPP
- Kaitocefalin
- LY-233053
- LY-235959
- LY-274614
- MDL-100453
- Midafotel (d-CPPen)
- NPC-12626
- NPC-17742
- PBPD
- PEAQX
- Perzinfotel
- PPDA
- SDZ-220581
- Selfotel; Antagonisti glicinovog mesta: 4-Cl-KYN (AV-101)
- 5,7-DCKA
- 7-CKA
- ACC
- ACEA-1011
- ACEA-1328
- Apimostinel (NRX-1074)
- AV-101
- Karisoprodol
- CGP-39653
- CNQX
- D-Cikloserin
- DNQX
- Felbamat
- Gavestinel
- GV-196771
- Harkoserid
- Kinurenska kiselina
- Kinurenin
- L-689560
- L-701324
- Likostinel (ACEA-1021)
- LU-73068
- MDL-105519
- Meprobamat
- MRZ 2/576
- PNQX
- Rapastinel (GLYX-13)
- ZD-9379; Antagonisti poliaminovog mesta: Arkain
- Co 101676
- Diaminopropan
- Dietilentriamin
- Huperzin A
- Putrescin; Nekompetitivni blokatori pora (uglavnom dizocilpinovo mesto): 2-MDP
- 3-HO-PCP
- 3-MeO-PCE
- 3-MeO-PCMo
- 3-MeO-PCP
- 4-MeO-PCP
- 8A-PDHQ
- 18-MC
- α-Endopsihozin
- Alaproklat
- Alazocin (SKF-10047)
- Amantadin
- Aptiganel
- Argiotoksin-636
- Arketamin
- ARL-12495
- ARL-15896-AR
- ARL-16247
- Budipin
- Koronaridin
- Delucemin (NPS-1506)
- Deksoksadrol
- Dekstralorfan
- Dekstrometadon
- Dekstrometorfan
- Dekstrorfan
- Dieticiklidin
- Difenidin
- Dizocilpin
- Efenidin
- Esketamin
- Etoksadrol
- Eticiklidin
- Fluorolintan
- Gaciklidin
- Ibogain
- Ibogamin
- Indantadol
- Ketamin
- Ketobemidon
- Lanicemin
- Levometadon
- Levometorfan
- Levomilnacipran
- Levorfanol
- Loperamid
- Memantin
- Metadon
- Metorfan
- Metoksetamin
- Metoksfenidin
- Milnacipran
- Morfanol
- NEFA
- Nerameksan
- Nitromemantin
- Noribogain
- Norketamin
- Orfenadrin
- PCPr
- PD-137889
- Petidin (meperidin)
- Fenciklamin
- Fenciklidin
- Propoksifen
- Remacemid
- Rinhofilin
- Rimantadin
- Roliciklidin
- Sabeluzol
- Tabernantin
- Tenociklidin
- Tiletamin
- Tramadol; Antagonisti ifenprodilovog (NR2B) mesta: Besonprodil
- Bufenin (nilidrin)
- CO-101244 (PD-174494)
- Eliprodil
- Haloperidol
- Izoksuprin
- Radiprodil (RGH-896)
- Rislenemdaz (CERC-301, MK-0657)
- Ro 8-4304
- Ro 25-6981
- Safaprodil
- Traksoprodil (CP-101606); NR2A-selektivni antagonisti: MPX-004
- MPX-007
- TCN-201
- TCN-213; Katjoni: Vodonik
- Magnezijum
- Cink; Alkoholi / isparljivi anestetici / povezani: Benzen
- Butan
- Hloroform
- Ciklopropan
- Desfluran
- Dietil eter
- Enfluran
- Etanol (alkohol)
- Halotan
- Heksanol
- Izofluran
- Metoksifluran
- Azotni oksid
- Oktanol
- Sevofluran
- Toluen
- Trihloroetan
- Trihloroetanol
- Trihloroetilen
- Uretan
- Ksenon
- Ksilen; Nepoznati/nerazvrstani antagonisti: ARR-15896
- Bumetanid
- Karoverin
- Konantokin
- D-αAA
- Deksanabinol
- Flufenaminska kiselina
- Flupirtin
- FPL-12495
- FR-115427
- Furosemid
- Hodžkinsin
- Ipenoksazon (MLV-6976)
- MDL-27266
- Metafit
- Minociklin
- MPEP
- Nifluminska kiselina
- Pentamidin
- Pentamidin isetionat
- Piretanid
- Psihotridin
- Transkrocetin (šafran)