MYO1F
MYO1F | |||||||||||||||||||||||||
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别名 | MYO1F;, myosin IF | ||||||||||||||||||||||||
外部ID | OMIM:601480 MGI:107711 HomoloGene:56276 GeneCards:MYO1F | ||||||||||||||||||||||||
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物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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mRNA序列 |
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蛋白序列 |
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基因位置(UCSC) | Chr 19: 8.52 – 8.58 Mb | Chr 17: 33.77 – 33.83 Mb | |||||||||||||||||||||||
PubMed查找 | [3] | [4] | |||||||||||||||||||||||
維基數據 | |||||||||||||||||||||||||
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MYO1F是一个位于人类17号染色体上的基因,該编码是一种隶属於肌凝蛋白超家族的蛋白肌凝蛋白-If(Myosin-If)。MYO1F编码的肌凝蛋白-If是一种非典型的肌凝蛋白,与编码肌凝蛋白-1MYH1是两种不同的基因。[5][6][7][8]
MYO1F基因主要在免疫系统中表达,其功能主要與细胞黏附,细胞移动有關[9]。而该基因的突变則与非综合征性耳聋有关[10]。
参见
参考资料
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ MYO1F Gene. GeneCards. [2021-05-02]. (原始内容存档于2021-06-04).
- ^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. Apr 1997, 40 (2): 332–41. PMID 9119401. doi:10.1006/geno.1996.4526.
- ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA. Mapping of unconventional myosins in mouse and human. Genomics. Feb 1997, 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488.
- ^ Entrez Gene: MYO1F myosin IF. [2021-05-02]. (原始内容存档于2010-12-05).
- ^ Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. October 2006, 314 (5796): 136–9. PMID 17023661. doi:10.1126/science.1131920.
- ^ Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ. MYO1F as a candidate gene for nonsyndromic deafness, DFNB15. Arch. Otolaryngol. Head Neck Surg. August 2001, 127 (8): 921–5. PMID 11493199. doi:10.1001/archotol.127.8.921.
拓展阅读
- Bement WM, Hasson T, Wirth JA, et al. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (14): 6549–53. PMC 44240
. PMID 8022818. doi:10.1073/pnas.91.14.6549.
- Krugmann S, Anderson KE, Ridley SH, et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell. 2002, 9 (1): 95–108. PMID 11804589. doi:10.1016/S1097-2765(02)00434-3.
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
- Olsen JV, Blagoev B, Gnad F, et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
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