ADCY8 |
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Identifiers |
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Aliases | ADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8 |
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External IDs | OMIM: 103070; MGI: 1341110; HomoloGene: 37443; GeneCards: ADCY8; OMA:ADCY8 - orthologs |
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Gene location (Mouse) |
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![Chromosome 15 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_15.svg/260px-Ideogram_house_mouse_chromosome_15.svg.png) | Chr. | Chromosome 15 (mouse)[1] |
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| Band | 15 D1|15 29.03 cM | Start | 64,568,933 bp[1] |
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End | 64,794,145 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - caput epididymis
- inferior olivary nucleus
- corpus epididymis
- external globus pallidus
- pons
- amygdala
- prefrontal cortex
- cingulate gyrus
- hypothalamus
- substantia nigra
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| Top expressed in | - ventral lateral nucleus
- central medial nucleus
- medial dorsal nucleus
- medial geniculate nucleus
- supraoptic nucleus
- lateral geniculate nucleus
- lumbar subsegment of spinal cord
- ganglion cell layer
- layer of neocortex
- efferent ductule
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/PBB_GE_ADCY8_206811_at_fs.png/250px-PBB_GE_ADCY8_206811_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - nucleotide binding
- metal ion binding
- lyase activity
- adenylate cyclase activity
- phosphorus-oxygen lyase activity
- calcium- and calmodulin-responsive adenylate cyclase activity
- ATP binding
- guanylate cyclase activity
- actin binding
- calmodulin binding
- protein homodimerization activity
- protein heterodimerization activity
- protein dimerization activity
- protein phosphatase 2A binding
| Cellular component | - integral component of membrane
- membrane
- plasma membrane
- guanylate cyclase complex, soluble
- Schaffer collateral - CA1 synapse
- hippocampal mossy fiber to CA3 synapse
- glutamatergic synapse
- integral component of presynaptic membrane
- intracellular anatomical structure
- integral component of plasma membrane
- caveola
- clathrin-coated pit
- postsynaptic density
- actin cytoskeleton
- basolateral plasma membrane
- apical plasma membrane
- axon
- dendrite
- neuronal cell body membrane
- plasma membrane raft
- membrane raft
- presynaptic active zone
- excitatory synapse
- cell junction
- clathrin-coated vesicle membrane
- cytoplasmic vesicle
- presynaptic membrane
- cell projection
- synapse
- postsynaptic membrane
| Biological process | - cAMP biosynthetic process
- intracellular signal transduction
- cellular response to glucagon stimulus
- cyclic nucleotide biosynthetic process
- long-term memory
- renal water homeostasis
- learning or memory
- signal transduction
- cGMP biosynthetic process
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- G protein-coupled receptor signaling pathway
- modulation of chemical synaptic transmission
- positive regulation of cytosolic calcium ion concentration
- memory
- locomotory behavior
- glucose mediated signaling pathway
- positive regulation of synaptic plasticity
- positive regulation of CREB transcription factor activity
- activation of protein kinase A activity
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- G protein-coupled opioid receptor signaling pathway
- glucose homeostasis
- protein complex oligomerization
- protein homooligomerization
- regulation of cytosolic calcium ion concentration
- cellular response to calcium ion
- cellular response to morphine
- cellular response to glucose stimulus
- regulation of cellular response to stress
- neuroinflammatory response
- positive regulation of long-term synaptic potentiation
- positive regulation of long-term synaptic depression
- cellular response to forskolin
- activation of adenylate cyclase activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001291903 NM_009623 NM_001331075 |
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RefSeq (protein) | | |
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NP_001278832 NP_001318004 NP_033753 |
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Location (UCSC) | n/a | Chr 15: 64.57 – 64.79 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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