GUCY1B3

Protein-coding gene in the species Homo sapiens
GUCY1B1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2WZ1, 3UVJ, 4NI2

Identifiers
AliasesGUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDsOMIM: 139397; MGI: 1860604; HomoloGene: 664; GeneCards: GUCY1B1; OMA:GUCY1B1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GUCY1B1
Genomic location for GUCY1B1
Band4q32.1Start155,758,992 bp[1]
End155,807,811 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for GUCY1B1
Genomic location for GUCY1B1
Band3|3 E3Start81,939,313 bp[2]
End81,981,996 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • orbitofrontal cortex

  • lateral nuclear group of thalamus

  • superior frontal gyrus

  • Brodmann area 46

  • postcentral gyrus

  • Brodmann area 23

  • Pars compacta

  • pons

  • entorhinal cortex
Top expressed in
  • olfactory tubercle

  • habenula

  • lateral septal nucleus

  • anterior amygdaloid area

  • globus pallidus

  • left lung lobe

  • ventromedial nucleus

  • dorsomedial hypothalamic nucleus

  • dorsal tegmental nucleus

  • mammillary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • guanylate cyclase activity
  • GTP binding
  • metal ion binding
  • protein binding
  • heme binding
  • lyase activity
  • phosphorus-oxygen lyase activity
  • signaling receptor activity
  • adenylate cyclase activity
Cellular component
  • plasma membrane
  • guanylate cyclase complex, soluble
  • cytoplasm
  • presynaptic active zone
Biological process
  • intracellular signal transduction
  • cyclic nucleotide biosynthetic process
  • blood circulation
  • nitric oxide-cGMP-mediated signaling pathway
  • cGMP biosynthetic process
  • nitric oxide mediated signal transduction
  • cellular response to nitric oxide
  • cGMP-mediated signaling
  • trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2983

54195

Ensembl

ENSG00000061918

ENSMUSG00000028005

UniProt

Q02153

O54865

RefSeq (mRNA)
NM_000857
NM_001291951
NM_001291952
NM_001291953
NM_001291954

NM_001291955

NM_001161796
NM_017469

RefSeq (protein)
NP_000848
NP_001278880
NP_001278881
NP_001278882
NP_001278883

NP_001278884

NP_001155268
NP_059497

Location (UCSC)Chr 4: 155.76 – 155.81 MbChr 3: 81.94 – 81.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[5][6]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[6]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[7] and Endothelial NOS.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
  6. ^ a b "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
  7. ^ a b Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

Further reading

  • Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. PMID 10977868.
  • Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. doi:10.1016/0014-5793(91)81248-7. PMID 1680753. S2CID 35130409.
  • Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486. S2CID 24237232.
  • Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461. S2CID 25406282.
  • Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. doi:10.1042/bj3350051. PMC 1219751. PMID 9742212.
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
  • Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
  • Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
  • Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi:10.1038/sj.ijir.3901461. PMID 16528291.
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