PTPN4

Protein-coding gene in the species Homo sapiens
PTPN4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CS5, 2VPH, 3NFK, 3NFL, 2I75, 5EZ0, 5EYZ

Identifiers
AliasesPTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDsOMIM: 176878; MGI: 1099792; HomoloGene: 2120; GeneCards: PTPN4; OMA:PTPN4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PTPN4
Genomic location for PTPN4
Band2q14.2Start119,759,922 bp[1]
End119,984,899 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PTPN4
Genomic location for PTPN4
Band1 E2.3|1 52.39 cMStart119,652,467 bp[2]
End119,837,613 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • granulocyte

  • cerebellar vermis

  • Achilles tendon

  • renal medulla

  • paraflocculus of cerebellum

  • Skeletal muscle tissue of rectus abdominis

  • corpus callosum

  • parietal lobe

  • pons
Top expressed in
  • lateral geniculate nucleus

  • medial geniculate nucleus

  • medial dorsal nucleus

  • cerebellar vermis

  • lobe of cerebellum

  • Region I of hippocampus proper

  • triceps brachii muscle

  • spermatid

  • superior colliculus

  • temporal muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein tyrosine phosphatase activity
  • phosphatase activity
  • cytoskeletal protein binding
  • protein binding
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • non-membrane spanning protein tyrosine phosphatase activity
Cellular component
  • cytoplasm
  • cytoplasmic side of plasma membrane
  • plasma membrane
  • cytoskeleton
  • membrane
  • nucleoplasm
  • cytosol
Biological process
  • protein dephosphorylation
  • peptidyl-tyrosine dephosphorylation
  • dephosphorylation
  • cellular response to cytokine stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5775

19258

Ensembl

ENSG00000088179

ENSMUSG00000026384

UniProt

P29074

Q9WU22

RefSeq (mRNA)

NM_002830

NM_019933

RefSeq (protein)

NP_002821

NP_064317

Location (UCSC)Chr 2: 119.76 – 119.98 MbChr 1: 119.65 – 119.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.[5][6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[6]

Interactions

PTPN4 has been shown to interact with GRID2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088179 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026384 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. Bibcode:1991PNAS...88.5867G. doi:10.1073/pnas.88.13.5867. PMC 51979. PMID 1648233.
  6. ^ a b "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".
  7. ^ Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.

Further reading

  • Gu M, Majerus PW (1996). "The properties of the protein tyrosine phosphatase PTPMEG". J. Biol. Chem. 271 (44): 27751–9. doi:10.1074/jbc.271.44.27751. PMID 8910369.
  • Gu M, Meng K, Majerus PW (1996). "The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12980–5. Bibcode:1996PNAS...9312980G. doi:10.1073/pnas.93.23.12980. PMC 24032. PMID 8917530.
  • Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.
  • Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933. S2CID 8132613.
  • Park KW, Lee EJ, Lee S, Lee JE, Choi E, Kim BJ, Hwang R, Park KA, Baik J (2001). "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG". Gene. 257 (1): 45–55. doi:10.1016/S0378-1119(00)00351-6. PMID 11054567.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Overview of all the structural information available in the PDB for UniProt: P29074 (Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)) at the PDBe-KB.
  • v
  • t
  • e
  • 2cs5: Solution structure of PDZ domain of Protein tyrosine phosphatase, non-receptor type 4
    2cs5: Solution structure of PDZ domain of Protein tyrosine phosphatase, non-receptor type 4
  • 2i75: Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)
    2i75: Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)
  • v
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Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class II
Class III
Class IV


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