VUF-8430
VUF-8430 | |||
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Preferentno IUPAC ime 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester | |||
Identifikacija | |||
Abrevijacija | VUF-8430 | ||
CAS registarski broj | 98021-17-1 ![]() | ||
PubChem[1][2] | 3063228 | ||
ChemSpider[3] | 2323820 ![]() | ||
ChEMBL[4] | CHEMBL1196470 ![]() | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C4H11N5S | ||
Molarna masa | 161.23 g mol−1 | ||
log P | -1,367 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
VUF-8430 je histaminski agonist[5] koji je selektivan za H4 tip receptora.[6]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). „Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury”. Neuroimmunomodulation 14 (6): 317–25. DOI:10.1159/000125048. PMID 18401194.
- ↑ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). „Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.”. Journal of Medical Chemistry 49 (23): 6650–1. DOI:10.1021/jm060880d. PMID 17154494.
Spoljašnje veze
![]() | Portal Hemija |
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Inhibitori: Aminoguanidin |
Histamin; Prekursori: L-Histidin; Kofaktori: Vitamin B6 |