TRPV4 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4DX1, 4DX2 | | |
Ідентифікатори |
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Символи | TRPV4, BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4 |
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Зовнішні ІД | OMIM: 605427 MGI: 1926945 HomoloGene: 11003 GeneCards: TRPV4 |
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Пов'язані генетичні захворювання |
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spondylometaphyseal dysplasia, Kozlowski type, metatropic dysplasia, Charcot-Marie-Tooth disease axonal type 2C, spondyloepiphyseal dysplasia, Maroteaux type, parastremmatic dwarfism, familial digital arthropathy-brachydactyly, neuromuscular disease, scapuloperoneal spinal muscular atrophy, autosomal dominant congenital benign spinal muscular atrophy[1] |
Онтологія гена |
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Молекулярна функція | • nucleotide binding • stretch-activated, cation-selective, calcium channel activity • osmosensor activity • microtubule binding • alpha-tubulin binding • SH2 domain binding • calmodulin binding • actin filament binding • ion channel activity • GO:0001948, GO:0016582 protein binding • beta-tubulin binding • cation channel activity • actin binding • ATP binding • protein kinase binding • protein kinase C binding • calcium channel activity • lipid binding • identical protein binding • зв'язування з іоном металу |
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Клітинна компонента | • integral component of membrane • cell projection • мембрана • focal adhesion • Філоподія • growth cone • Адгезивні контакти • клітинна мембрана • ruffle membrane • cell surface • міжклітинні контакти • apical plasma membrane • cortical actin cytoskeleton • cytoplasmic microtubule • GO:0016023 cytoplasmic vesicle • lamellipodium • integral component of plasma membrane • війка • ендоплазматичний ретикулум |
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Біологічний процес | • actin cytoskeleton reorganization • cell volume homeostasis • cellular response to heat • positive regulation of inflammatory response • negative regulation of neuron projection development • glucose homeostasis • cellular hypotonic salinity response • positive regulation of chemokine (C-X-C motif) ligand 1 production • positive regulation of cytosolic calcium ion concentration • calcium ion import • positive regulation of monocyte chemotactic protein-1 production • response to mechanical stimulus • negative regulation of brown fat cell differentiation • osmosensory signaling pathway • cellular calcium ion homeostasis • hyperosmotic salinity response • microtubule polymerization • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of JNK cascade • cellular hypotonic response • ion transport • секреція вазопресину • cellular response to osmotic stress • regulation of response to osmotic stress • diet induced thermogenesis • response to osmotic stress • response to insulin • GO:1901313 positive regulation of gene expression • positive regulation of vascular permeability • calcium ion transmembrane transport • cortical microtubule organization • positive regulation of chemokine (C-C motif) ligand 5 production • cell-cell junction assembly • positive regulation of ERK1 and ERK2 cascade • hypotonic response • positive regulation of macrophage inflammatory protein 1 alpha production • blood vessel endothelial cell delamination • multicellular organismal water homeostasis • positive regulation of macrophage chemotaxis • calcium ion transport • positive regulation of microtubule depolymerization • actin filament organization • трансмембранний транспорт • cartilage development involved in endochondral bone morphogenesis • energy homeostasis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001177428 NM_001177431 NM_001177433 NM_021625 NM_147204 |
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RefSeq (білок) | | NP_001170899 NP_001170902 NP_001170904 NP_067638 NP_671737 |
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Локус (UCSC) | Хр. 12: 109.78 – 109.83 Mb | Хр. 5: 114.76 – 114.8 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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